I would have to see this in order to fully understand what’s happening, but I think I have an idea.
When you click on load more, it calls the next set up posts from the next page.
If you have a plugin which is adding functionality to the first set of posts, it needs to be re-run when the new posts are loaded in order to work on those posts.
This is something that would have to be done by the plugin developer of whatever plugin you’re using to preview.
Let me know if that makes sense.