Hi Chris,
This would be possible through adding a custom class to the Block, and then using this class as a selector when creating a Typography setting in Appearance > Customize > Typography.
Example, added my-custom-paragraph
class to this Paragraph Block: https://share.getcloudapp.com/2NuzZGmj
Then, in Appearance > Typography, I created a new font setting in the Typography Manager, and set the Target Element to Custom – my-custom-paragraph
.
See: https://share.getcloudapp.com/X6uEyZQG
As can be seen, I am able to change the font of this specific paragraph Block now.
Hope this helps! 🙂